Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones
نویسندگان
چکیده
منابع مشابه
Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones.
We synthesized a new series of conjugated hydrazones that were found to be active against malaria parasite in vitro, as well as in vivo in a murine model. These hydrazones concentration-dependently chelated free iron and offered antimalarial activity. Upon screening of the synthesized hydrazones, compound 5f was found to be the most active iron chelator, as well as antiplasmodial. Compound 5f a...
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Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation in tumorigenesis. Although the cellular mechanisms that regulate Smo function remain unclear, the direct inhibition of Smo by cyclopamine, a plant-derived steroidal alkaloid, suggests that endogenous...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2016
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01575-15